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Under the circumstances, Mr. Upton is showing clear signs of fatigue.

“You’ve got metal detectors now going on the House floor. We get really nasty threats at home. The tone gets, you know, tougher and tougher, and it’s a pretty toxic place,” he said last month on CNN. “I’ve never seen anything like this before.”

None of the 10 have fallen so far in the Republican firmament as Ms. Cheney, nor risen so high in the esteem of many in both parties who fear and loathe Mr. Trump. The daughter of a former vice president who was once the embodiment of confrontational conservatism, for better or worse, Ms. Cheney started 2021 as the chairwoman of the House Republican Conference, a political knife fighter believed by many to be destined for the speakership.

Her vote to impeach, and her outspoken denunciations of the lie — pushed by Mr. Trump and embraced by many of her colleagues — that the 2020 election was “stolen,” cost her dearly. She was ousted from her leadership post, ejected from the Wyoming Republican Party and targeted repeatedly by the former president, who has tried to unite Wyoming voters around the primary opponent he has endorsed, Harriet Hageman.

Ms. Cheney has soldiered on, becoming the vice chairwoman of the House select committee investigating the riot, the face of Republican resistance to Trumpism and a one-woman wrecking crew for Mr. McCarthy’s ambitions to become speaker next year if the party retakes control of the House.

Looking back, Ms. Cheney said in an interview that her fall from Republican leadership was inevitable as long as she had to share the stage with Mr. McCarthy, whose brief denunciation of Mr. Trump after Jan. 6 quickly gave way to a resumption of fealty.

“It was increasingly clear that staying as conference chair was going to require me to perpetuate the lie about the election,” Ms. Cheney said. “I was simply not willing to look the other way and accept what he did.”

Mr. McCarthy, by contrast, visited Mr. Trump at his Mar-a-Lago club in Palm Beach, Fla, near the end of January, making it “pretty clear the path that he had chosen,” Ms. Cheney added. “It was one that was not faithful to the Constitution.”