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“There’s a reason why people question the trustworthiness of Hillary Clinton — and that’s because they’re paying attention,” Mr. Pence said in his contentious debate (at least by the standards of 2016) with Mr. Kaine.

He speaks quickly, rarely leaving a space between sentences for an opponent to jump in. “He is a very consistent, smooth, regulated debater,” said John D. Podesta, who was Mrs. Clinton’s campaign chairman in 2016. “His experience as a radio host taught him to be well prepared. He’ll be the anti-Trump in this debate. It will be the opposite of what you saw last Tuesday.”

“He’ll come in at you,” Mr. Podesta said. “He’ll come well prepared. He can go on the attack. It will be very modulated, silky.”

Ms. Harris has proved to be an intense and effective interlocutor as a member of the Senate Judiciary Committee. She raised her stock with Democrats with her aggressive questioning of, among other officials, William P. Barr, the attorney general.

In a debate, she can be withering and methodical, staring down at a lectern scribbling notes while waiting for her turn to speak, before moving in for the attack.

“Steve, I think you really should not go below the dignity of this debate or the office that we seek,” Ms. Harris said when Steve Cooley, the Los Angeles district attorney and her opponent in the 2010 race for California attorney general, accused her of failing to seek the death penalty in a murder case as the San Francisco district attorney.

“She will be prepared with certain specific, tested statements or lines,” Mr. Cooley said in an interview, recalling their meeting in 2010. He said that was on display in the Democratic debates when Ms. Harris attacked Mr. Biden for his record of opposition to busing.