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There are intraparty fights to deal with, as well. Senator Joe Manchin III of West Virginia announced his opposition to the voting rights legislation that Ms. Harris was championing for the administration, and he was expected to be in the hot seat Tuesday afternoon during a caucus luncheon. And a group of bipartisan senators, including two Democrats who were invited to the dinner, Kyrsten Sinema of Arizona and Jeanne Shaheen of New Hampshire, has unveiled an alternative to the president’s infrastructure plan that does not address key Democratic priorities, like climate change. The plan does not have the support of a majority of Republicans, and progressives like Senator Bernie Sanders, independent of Vermont, have already come out against it.

Ms. Harris has not been a key player in infrastructure negotiations and was not known for her close relationships with colleagues on Capitol Hill during her four years in the Senate, a chunk of which she spent running for president.

But as vice president — and the tiebreaking vote in the evenly divided Senate — she has taken on some of the administration’s most difficult goals. Besides the voting rights push, Ms. Harris has also been tasked with stemming the flow of migrants to the U.S. border with Mexico by addressing the root causes in countries like Guatemala that push migrants north.