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“On Nov. 3, Wisconsin will decide whether we will quickly return to record prosperity, or whether we will allow Biden and the Democrats to impose a $4 trillion tax hike, ban American energy, confiscate your guns” and “shut down the economy,” Mr. Trump said, in remarks that significantly distorted Mr. Biden’s agenda. He also proclaimed Speaker Nancy Pelosi “crazy as a bedbug” and said he looked forward to seeing what Vice President Mike Pence “does to” Mr. Biden’s running mate, Senator Kamala Harris of California, in their debate next month.

Mr. Biden, often seeming to be in a punchy mood, lobbed his own attacks on Mr. Trump’s sense of reality.

“He may be really losing it — he’s president,” Mr. Biden said, as he addressed the civil unrest that has played out in some American cities. “I am not the president. This is Donald Trump’s America. You feel safer in Donald Trump’s America?”

Mr. Biden’s appearance came as he sought to center the presidential campaign on the response to the coronavirus. On Wednesday, he stepped up his warnings that Mr. Trump was politicizing the rollout of a vaccine, and at the town hall, he discussed the issue at length, stressing his deference to scientists even as he described the staggering uncertainties that would accompany the successful deployment of a vaccine.

The opinion of the federal government’s top infectious disease expert would be important, he said. “I don’t trust the president on vaccines,” he said. “I trust Dr. Fauci. If Fauci says a vaccine is safe, I’d take the vaccine.”

Throughout the event, Mr. Biden blasted Mr. Trump’s handling of the coronavirus crisis — as he has many other times in recent months — and pointed to revelations from a new book by the journalist Bob Woodward that the president had knowingly minimized the risks of the coronavirus. He also sought to connect many voters’ questions back to that subject.

But the issues that arose were wide-ranging, and Mr. Biden, who visited firefighters after the event, seemed keenly attuned to the politics of Pennsylvania.