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The C.D.C. stopped short of telling even fully vaccinated people that they could shed their masks outdoors altogether — citing the worrying risk that remains for transmitting the coronavirus, unknown vaccination levels among people in crowds and the still-high caseloads in some regions of the country. The guidance also cautioned even vaccinated people against going without masks in medium-size outdoor gatherings.

But even the C.D.C.’s director, Dr. Rochelle Walensky, emphasized a more expansive interpretation, telling reporters at a White House briefing, “We no longer feel that the vaccinated people require masks outdoors,” outside “large public venues, such as concerts, stadiums and things like that.”

The order had immediate ripple effects in the states. Governors in California, New York, Louisiana, Maine and Massachusetts all relaxed outdoor mask mandates after the C.D.C.’s announcement. In Tennessee, Gov. Bill Lee, a Republican, went much further, ignoring the federal government’s advice as he declared it was “time for celebrations and weddings and conventions and concerts and parades and proms” to take place “without limits on gathering sizes.”

On Capitol Hill, a group of Republican lawmakers who are also medical professionals released an advertisement on Tuesday encouraging vaccination, in which they appeared wearing white coats with stethoscopes draped around their necks. Senator Roger Marshall, a freshman Republican from Kansas and a medical doctor, told viewers that the reason to get vaccinated was simple: “So we can throw away our masks, and live life as free as before.”

Mr. Marshall, who organized the effort, said it was based on research conducted by Frank Luntz, a Republican pollster working to reduce vaccine hesitancy among conservatives. In an interview, Mr. Luntz said Mr. Biden’s announcement was a positive step, and could give people who are reluctant to get vaccinated a reason to get their shots.