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The U.S. death toll from Covid rose to an average of more than 2,400 fatalities per day over the previous seven days as of Monday, according to Johns Hopkins data.

Jennifer Nuzzo, head of epidemiology at Johns Hopkins Covid Resource Center, said Covid deaths may rise even more, because states with lower vaccination rates got hit later by omicron and haven’t experienced the full brunt of the variant yet.

“Any time we have deaths after the development of a vaccine — [which] largely takes off the table the possibility of death — is a tragedy,” Nuzzo said. “There’s no way around that this is a bad development for the pandemic.”

Dr. Shereef Elnahal, CEO of Newark, New Jersey-based University Hospital, said it’s not yet clear if his facility is fully over the hump in Covid-related deaths in this wave. After an increase in deaths over the past couple of weeks, the hospital has seen a plateau in ICU patients and fatalities.

About half as many patients who come in with Covid end up needing intensive care in this wave as compared with previous surges, Elnahal said.

“It’s just so transmissible that the absolute numbers of people needing ventilators looked similar to previous waves,” he said.

Some parts of the country are seeing encouraging signs, and cases and hospitalizations are easing nationwide. Hopkins data shows that U.S. cases surged to a pandemic high of close to 1 million new infections a day in mid-January. The country is now reporting a seven-day average of about 450,000 new cases per day, down 36% over the past two weeks.

The number of patients currently in U.S. hospitals with Covid — 140,000 — is also down from the recent peak of 159,400 on Jan. 20, according to a seven-day average of Department of Health and Human Services data.

This easing is most evident in the Northeast, where cases rose as the omicron variant spread earlier there than in other parts of the country. Cases and hospitalizations are falling more sharply in that region than others, but it’s now feeling the effects of getting hit first by omicron, with population-adjusted daily deaths higher than anywhere else.

The number of ChristianaCare patients has declined by 33% in recent weeks, but its hospitals were still operating at 99% capacity as of late last week. That includes patients who came to the hospital because of Covid as well as those who were admitted for something else and then tested positive. All patients who test positive for Covid, regardless of why they were admitted, need extra care and resources to isolate them from other patients and staff, which taxes the system, Silverstein said. 

“There are a lot of sick people, with Covid and because of Covid,” he said.

A shortage of monoclonal antibodies, which were standard care for Covid patients before they proved little use against omicron, also has forced ChristianaCare to make “clinical prioritization decisions about who’s most eligible,” Silverstein said. “Not who’s eligible, who’s most eligible.”

The mortality rates, the percentage of people with Covid who ultimately die from the virus, are lower in the Northeast during this wave than previous surges. But other parts of the country that have lower vaccination rates may not be as lucky, doctors say.

“When you look at the delta period and last winter, as cases increased, hospitalizations and deaths increased in a similar pattern,” Centers for Disease Control and Prevention Director Dr. Rochelle Walensky told reporters last week.

“Strikingly, when we compare the past month when omicron was the predominant variant, we see a clear separation between cases, hospital admissions and deaths,” she said. She attributed the lower death rates to the vaccines, which have proven to provide good protection against death from Covid.

Cases are five times higher than they were during the delta wave, Walensky said, but hospitalizations and deaths haven’t increased at the same rate.

Nuzzo said the current wave of infection, hospitalization and death would have been much worse without the vaccines.

“Part of why omicron looks more mild is because it is finding societies that have already amassed a fair amount of immunity from prior infection or vaccination,” Nuzzo said.

In the New York and New Jersey area, “many of the cases did not become fatal and/or extremely serious because of the high vaccination rates,” said Perry N. Halkitis, dean of the Rutgers School of Public Health. “But in the rest of the country, that may not be the case.”

That’s both because of lower vaccination rates and because of less-robust hospital health care in other parts of the country, he said, which could even mean a peak in total deaths in those areas, surpassing those from last winter’s surge.