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“These quarantines aren’t easy on anybody,” he said.

But leaders have painted an increasingly bleak picture if Californians fail to heed guidelines.

Mayor Eric Garcetti of Los Angeles, who was also in quarantine after his 9-year-old daughter tested positive for the virus, on Monday evening described the surge pummeling the nation’s second biggest city as “the greatest challenge” it has ever faced. He pleaded with Angelenos to stay home; there’s not much more officials can do otherwise.

“There’s not a lot left to close,” he said.

[If you missed it, here’s what to know about the regional stay at home orders.]

Dr. Mark Ghaly, the state’s secretary of health and human services, said in Monday’s news conference that health care providers and state and local leaders were working frantically to prevent the state’s health care systems from tipping into what he and the governor described as crisis mode.

“We continue to build up our capacity,” he said. “When we look forward to that forecast of quite a few patients toward the end of January — that’s not a story that’s already been written.”

But as has been the case in the last couple of months, making sure health care facilities are sufficiently staffed has been the biggest hurdle. Nurses, doctors, janitors and so many others are exhausted. Help from other states and the federal government is scarce as so much of the nation suffers from the rapid spread of Covid-19.

[See the intensive care unit capacity at hospitals near you.]

In the next week or so, more Californians could hear that many hospitals are simply full. Patients who are unable to avoid going to the hospital will encounter hourslong waits in hallways.